Homeogenetics - Revision history

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{{Infohom|971|Homeogenomics: Veränderung der Genexpression durch Homöopathie|24.7.18}} Translated by DeepL.com

==Change in gene expression through homeopathy ==

Homeogenomics are molecular biological studies that are intended to contribute to the understanding of the interactions between homeopathic preparations and the human genome <ref> Kay PH, Khuda-Bukhsh AR: The contribution of homeogenomic and homeogenetic studies in the support of the practice of Homoeopathy. [http://www.ijrh.org/article.asp?issn=0974-7168;year=2016;volume=10;issue=2;spage=101;epage=107;aulast=Kay Indian J Res Homoeopathy 2016;10: 101-107] </ref>.

Homeogenomics" is a research field in the field of basic homeopathic research that has so far been little perceived. The effects of potentised homeopathic drugs on the human genome have been described for almost 20 years. A review of this has recently appeared in a journal of the ARH, which concisely summarizes the work of the last 20 years <ref name="a"> Kay PH, Khuda-Bukhsh AR: An introduction to homeogenomic considerations in innovation of high dilution technology. Homeopathy in practice, Spring/Summer 2016, p.46-52 (http://www.a-r-h.org) </ref>. Previous studies have shown that these interactions actually exist, for example in the up- and down regulation of certain genes that alter their expression and activity. It is hoped that the exact analysis of the genes influenced by a homeopathic substance could support the selection of the individual homeopathic remedy for the patient. In oncology in particular, some drugs have already been studied in detail.
Professor Anisur R. Khuda-Bukhsh from Kalyani/India, who is now emeritus, plays a central role in previous research: As a former director of the Zoological Institute of the University of Kalyani, he has published around 320 works, many of them in high-ranking international journals. In 1997 appeared the first important work on this topic, which postulated the effect of homeopathic agents on the genome <ref>[3] Khuda-Bukhsh AR: Potentized homoeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vitro. Complement Ther Med 1997 (5): 43-46</ref>. Since then, numerous works by various authors and working groups have appeared that support these assumptions. Some examples of how homeopathic preparations can influence the expression of numerous genes (see references under <ref name="a" />)
*''Gelsemium sempervirens'' acts on the up- and down regulation of at least 49 genes, including six genes that regulate human neuroblastoma cells. Also for ''Hydrastis canadensis'' and ''Condurango'' such effects have been studied.
*Whether such effects on the genome also have concrete, positive effects for patients is currently being investigated. For example, certain inflammatory mediators seem to be addressed that play a role in autoimmune diseases or allergies.
*In the field of oncology there are approaches to investigate gene regulation in terms of apoptosis, cell cycle regulation, autophagy and angiogenesis. For example, the focus is on the tumour suppressor gene TP53, which encodes the protein p53. The latter plays an important role in angiogenesis and the activation of repair proteins. *Effects of ''Phytolacca decandra'', ''Condurango, Thuja officinalis, Carcinosinum'' and ''Lycopodium clavatum ''(in different potencies, from mother tinctures to C200) could already be shown.
Epigenetics is investigating how these changes in gene expression take place in detail. DNA methylation plays an important role in this process. Among other things, the promoter region of TP53 was investigated and the effect of ''Condurango'' on demethylation in the context of an epigenetic modification of cancer cells was demonstrated. Similar effects are described for ''Hydrastis canadensis ''.
Kay and Khuda-Bukhsh conclude from the previous data that "homeogenomic and homeogenetic" considerations could pave the way for the development of an effective therapy system in the sense of personalized medicine<ref name="a"/>.    
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 *Whether such effects on the genome also have concrete, positive effects for patients is currently being investigated. For example, certain inflammatory mediators seem to be addressed that play a role in autoimmune diseases or allergies.
 *In the field of oncology there are approaches to investigate gene regulation in terms of apoptosis, cell cycle regulation, autophagy and angiogenesis. For example, the focus is on the tumour suppressor gene TP53, which encodes the protein p53. The latter plays an important role in angiogenesis and the activation of repair proteins. *Effects of ''Phytolacca decandra'', ''Condurango, Thuja officinalis, Carcinosinum'' and ''Lycopodium clavatum ''(in different potencies, from mother tinctures to C200) could already be shown.
 *Epigenetics is investigating how these changes in gene expression take place in detail. DNA methylation plays an important role in this process. Among other things, the promoter region of TP53 was investigated and the effect of ''Condurango'' on demethylation in the context of an epigenetic modification of cancer cells was demonstrated. Similar effects are described for ''Hydrastis canadensis ''.
 <p style="text-align: justify">Kay and Khuda-Bukhsh conclude from the previous data that "homeogenomic and homeogenetic" considerations could pave the way for the development of an effective therapy system in the sense of personalized medicine<ref name="a" />.</p> <p style="text-align: justify">&nbsp;</p> <p style="text-align: justify">&nbsp;</p>
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